Polynucleotides are an injectable biostimulator which helps improve and rejuvenate the skin. Polynucleotides are one of the latest regenerative medicine advancements in aesthetic medicine, but have been used medically in hospitals for decades to help with burns and wound healing and are backed by extensive clinical data. Polynucleotides are made up of chains of nucleotides that are building blocks of DNA and RNA. They are responsible for cell regeneration and repair. They are derived from Salmon or Trout DNA which is intensely purified. As we age, the skin produces less collagen and elastin, which increases signs of aging like wrinkles and sagging. Polynucleotides promote the production of collagen and elastin by stimulating the fibroblasts, increases hydration, reduces pigmentation, and has antioxidant properties. This helps to reduce the signs of aging. What are the benefits? · Enhances skin quality and texture · Reduces fine lines and wrinkles · Boosts hydration through enhanced hyaluronic acid production · Diminishes pigmentation and dark circles · Improves the appearance of scarring · Exhibits anti-inflammatory properties which can help with conditions such as rosacea · Aids in wound healing · Can be used to address hair loss Areas which can be treated include areas such as the face including under the eyes, neck, décolletage and the scalp. For optimal results, at least three sessions are recommended, ideally three weeks apart. A maintenance session is required approximately 6-9 months depending on individual factors such as lifestyle, age, diet and use of sunbeds etc. Results vary between patients, but results are usually visible by 3-4 weeks after the first treatment. Is there any downtime? After the treatment, there can be small bumps at the injection sites which generally disappear within 24 to 48 hours. As with any injectable treatment, there may be some temporary bruising, redness, and swelling. There is a small risk of infection which can be minimised with good aftercare eg avoiding touching or washing area for at least 4 hours and avoid wearing make up for 12 hours. Is the treatment painful? To reduce discomfort, numbing cream is applied before the procedure. Can Polynucleotides be used alongside other treatments? Polynucleotides can be used to rejuvenate the skin alongside other injectables such as anti-wrinkle treatments, skinboosters or dermal fillers. They can also be used to prime the skin before treatments such a lasers or chemical peels to help improve the effects of the treatment and reduce the downtime. How are Polynucleotides different to Dermal Fillers or Skinboosters? While both polynucleotides provide hydration, skinboosters do not have a regenerative effect. Dermal fillers can provide volume whilst polynucleotides do not. Polynucelotides are good treatment option for patients who want to improve their skin quality without adding volume. In addition, the result of dermal fillers can be noticed immediately but results from polynucleotides can take weeks. Who is not suitable for treatment? · Pregnant or breastfeeding · Active skin infection/herpes infection in the area of treatment · Fish allergy- may require patch test before treatment · Previous or ongoing or autoimmune disease · Hypersensitivity or Allergy to polynucleotide products Your medical history will be reviewed at the consultation. What products are used? Dr Oteri uses the renowned brands Plinest and Newest for Polynucleotide treatments. Plinest Eye is specifically tailored for the delicate eye area, while Plinest can be applied to various regions. Newest combines polynucleotides with hyaluronic acid, offering regenerative effects along with skin hydration and plumping. Treatment cost: A single session £275. Three sessions £750 If you would like further information or to get booked in, please contact the practice. A consultation is required prior to treatment. By Oke Oteri, Dental Surgeon